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The renal excretion of creatinine is regarded as relatively constant over the day in healthy individuals, allowing to calculate metabolite/creatinine ratios, typically presented as g metabolite per gram of creatinine (g/g creatinine) (Johner et al

(19, 77) systematically demonstrated LPA (18:1) activates RhoA and NF-B through AKT/IB signaling, promoting functional invadopodia formation and enhancing PC-3 cell invasive capacity

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