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EDTA is a chelating agent widely present in industrial, cosmetic and food products

The attachment of IgE-allergen immune complexes to FcRI activates tyrosine kinases such as Lyn, Fyn, and Syk that subsequently phosphorylate a variety of signaling molecules such as LAT, SLP-76, and PLC-1 and lead to mast cell degranulation

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Some studies have found that either Streptococci (73) or Alistipes (76) may be responsible for the IBS symptoms