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Med Sci Monit 12:3645 Breese GR, Cooper BR, Prange AJ, Cott JM, Lipton MA (1974) Antagonism of ethanol narcosis by thyrotropin releasing hormone

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Studies have also indicated interactions with opioid pathways DSIP administration has been shown to modulate pain perception and has effects that can be partially blocked by opioid antagonists in some paradigms, suggesting opioidergic involvement in at least some of its actions