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GHS-R1b is a truncated splice variant containing only five transmembrane domains that does not signal in response to ghrelin or GHRPs, but it does heterodimerize with GHS-R1a and attenuate its signaling efficiency in a dominant-negative manner

Sec is a rare amino acid, being found in only 25 human proteins, and in nearly all situations it is found in the active site of a redox-active enzyme [56, 57]