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This heightened metabolic activity naturally produces more free radicals

Frye RE, et al

It is derived from the 177-191 amino acid sequence of hGH, which is responsible for stimulating fat metabolism without affecting muscle growth, blood sugar regulation, or insulin-like growth factor-1 (IGF-1) levels

Similarly, in a critical-size calvarial defect model, the inclusion of tetrameric CPPs in ex vivo transduction of recombinant adenovirus expressing BMP-2 into MSCs promoted highly mineralized bone formation [201]