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The intranasal (nose-to-brain) administration method offers a number of advantages, as it avoids first pass effect, is less intrusive, provides a broad surface area for absorption, and reduces nontargeted delivery to minimize systemic exposure [7, 25]

Tian C, Liu Y, Li Z, Zhu P, Zhao M

For subcutaneous injections, a standard insulin syringe is ideal

However, other studies have implied that multiple IgG molecules can bind to the same pathogen and that the antibody array on the surface of pathogen allows for multivalent interactions with the mucin network, creating an avidity effect sufficient to effectively trap pathogens 85