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Nicotine could contribute to this progression by aggravating vasoconstriction, although other tobacco smoke toxins are also likely to be contributing to progressive vascular injury. In laymans terms this tells us that nicotines impact as a vasoconstrictor (shrinking blood vessels which increases blood pressure) can contribute, alongside the other chemicals in cigarette smoke, to more severe conditions brought about by prolonged hypertension

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In July 2022, the FDA announced plans to draft regulations to establish a maximum nicotine level for cigarettes and other combustible tobacco products