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The Bonini lab developed a fly impactor model using a piezoelectric striker to compress the fly head against a metal fly collar that fixes the head in place and demonstrated acute injury markers that progressed with increasing severity, establishing a more realistic single TBI model in Drosophila (136, 140)
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Variants in JAK2, TYK2, STAT1, STAT3, STAT4 genes increase UC susceptibility [19], and JAK3 knockout mice develop severe combined immunodeficiency, affecting T and B cell development, resulting in IEC differentiation defects and impaired intestinal barrier function, thus increasing susceptibility to UC [131]
Addressing this accumulated damage requires regenerative processes the peptide appears to stimulate
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