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LME models further confirm that Shannon diversity increases with time in toddlers, while in adults and adolescents it remains at very similar values during the sampling period (Supplementary Figure S1B)

Results observed in laboratories do not always translate directly into predictable outcomes for every person

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Moreover, neuropathological examination of MS tissue indicates that degeneration, CNS atrophy, and myelin loss are most prominent in the progressive stage, when lymphocytic inflammation paradoxically wanes