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The practice existed in a regulatory gray zone but was not actively prohibited

Fibroblasts adhere better to the damaged substrate, migrate to the repair zone, and produce more extracellular matrix (collagen, fibronectin)

Compounded peptides are sometimes offered when branded medications are expensive or in short supply, but the FDA has warned that compounded semaglutide and tirzepatide may not meet the same safety or quality standards as FDA-approved products (FDA statement on compounded semaglutide)