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In areas of endemic goiter, changes in thyroid size reflect long-term iodine nutrition (months to years)

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Studies of the long-term consequences of the use of I on the occurrence and development of AITD clearly demonstrated that the early increase in thyroid antibodies is mostly transient, differs between populations under the influence of genetic and environmental factors, and does not always coincide with the presence of AITD or its further development (54)