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When the body perceives significant energy deficit or metabolic stress, it may suppress reproductive function as a protective mechanism

J Trauma Acute Care Surg 82:566574 Chung SS, Kim M, Youn B-S, Lee NS, Park JW, Lee IK, Lee YS, Kim JB, Cho YM, Lee HK (2009) Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor in human skeletal muscle cells

Finally, whilst various randomised trials have assessed combination therapies, no two trials have investigated the same combination of therapy, meaning little meaningful recommendation can be made for any individual combination treatment

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