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At higher levels, when ROS levels overtake cellular antioxidant defenses, it leads to significant DNA damage, increased lipid peroxidation (LPO), and oxidative stress (OS)

A recent clinical trial with smokers (randomized, double-blind placebo-controlled design) also supports the role of amla fruit as a relevant option of natural antioxidants [42]

In many places, sections from mice given betaine (group IV) showed a moderate (++) level of immunological expression of GFAP, as shown in Figs

Given its potent redox capabilities, and its high intracellular concentration and widespread distribution, its role as a potent defense mechanism against oxidative and electrophilic stress is well-established