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PT-141 (Bremelanotide) Best for: Low libido and hypoactive sexual desire linked to hormonal shifts in perimenopause Mechanism: PT-141 is a synthetic melanocortin peptide derived from alpha-melanocyte stimulating hormone (a-MSH) that activates MC3R and MC4R receptors in the hypothalamus, triggering dopaminergic pathways that drive psychological motivation for intimacy