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Funding This study was supported by grant from National Natural Science Foundation of (82100806, 82270802, 82170775, 82370765), The Open Project of Hubei Key Laboratory 2023KFZZ009 and The Fundamental Research Funds for the Central Universities 2042023kf0022

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The methylation signatures observed in AK exhibit canonical characteristics of oncogenic methylation patterns and demonstrate a certain resemblance to the epigenetic profiles of cSCC, which mainly showed typical features of stem cell methylomes [149]