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Compound 18 significantly reduced the levels of TNF-, IL-6, COX-2, and iNOS in LPS-stimulated BV-2 microglial cells

First, the vast majority of available data derives from animal studies, and extrapolation to human applications may not be straightforward due to species differences in physiology and drug metabolism

Free heme is dangerous in excessive quantities (15) which is why it is quickly removed from tissues through hydrolyzation by microsomal heme-oxygenase, specifically at the -methane bridge

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