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Glutathione levels decline with age, chronic illness, high oxidative load (alcohol, medications, pollution, chronic stress), and acute illness

While several epidemiological and clinical studies have explored the benefits of polyphenol consumption, limitations such as small sample sizes, lack of controls, varied methodologies, and heterogeneous data correlations have been observed

Discussion As one of the most complex biological processes that occur during human life, the wound repair process involves four steps that include inflammation around the site of injury, angiogenesis and the development of granulation tissue, repair of the connective tissue and epithelium, and ultimately remodeling that leads to a healed wound.1 The clinical treatment of skin loss due to severe and massive burns or wounds continues to be a major problem in surgical procedures