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While the body is designed to handle trace amounts, the cumulative effect of these exposures is what typically leads to a feeling of being "overloaded." Water Sources: Even in developed areas, older infrastructure can contribute to trace amounts of lead or copper in drinking water

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Though abiotic stresses such as drought, salinity, heat, cold light, wounding and senescence can modulate MT gene expression in plants (references cited in Sekhar et al., 2011), among metals, Cu, Cd, Pb, and Zn can strongly induce the plant MT gene expression (reviewed by Mehes-Smith et al., 2013)

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