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In mice, MDSCs are defined by the expression of Gr-1 + and CD11b + and are subdivided into two main subsets: polymorphonuclear (PMN)-MDSCs, characterized by CD11b + , Ly6G high , Ly6C low , CD117 + , and monocytic (M)-MDSCs, which express CD11b + , Ly6C high , Ly6G low , these subsets function predominantly to suppress T-cell activation via several pathways