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Note: Research applications vary by model system, endpoints, and lab protocols

Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state

The geometries of the refined structures were analyzed and validated using MolProbity 36

Moreover, the switch to aerobic glycolysis from OXPHOS protects tumor cell mitochondria from damage caused by electron leakage, thereby reducing the potential sources of ROS