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This massive trial aims to map the exact restoration of brain GSH and assess exact symptom improvements, potentially establishing NAC as a standard-of-care intervention for the profound neuroinflammation seen in ME/CFS

We summarize mechanistic insights across cellular and molecular domains, critically appraise preclinical and clinical findings, and discuss translational challenges that include bioavailability and brain penetration, study heterogeneity, biomarker guided stratification, and pediatric safety