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Its not a medication, and its not approved for human or animal use outside of authorized studies 5-Amino-1MQ is a small-molecule research compound supplied for in-vitro investigation into metabolic and enzymatic signaling pathways, particularly through its activity as an inhibitor of nicotinamide N-methyltransferase (NNMT)

On the other hand, berberine can inhibit ERK phosphorylation (Lu et al., 2010), and induce the phosphorylation of Liver kinase B1 (LKB1) (Ser428), calcium/calmodulin-dependent protein kinase II (CaMKII) (Thr286), and AMPK (Thr172) (Lu et al., 2010)

[33] These are thought to be due to defective DNA synthesis inhibiting replication in tissue sites with a high turnover of cells

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