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the 1 mg arm is the lowest measured human pharmacologic activity: Frias Lancet 2018

Key safety practices include: Proper hand hygiene Using sterile equipment Correct needle disposal Maintaining patient records Following infection control guidelines These topics are covered in detail in most professional training programmes

Nature Medicine 21(8):887-894

Noyce said he'd seen people, mostly in their teens and twenties, at the hospital who were "really very disabled" from using high quantities of nitrous oxide, needing to use a walking frame or wheelchair, and others who were incontinent or unable to get an erection