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GHK-Cu's broad gene modulation affecting 31.2% of human genes per Broad Institute analysis produces compounding benefits as repair pathways remain upregulated across multiple cycles (Pickart & Margolina, 2018)

In those, loss of NRF2 resulted in a more rapid onset and more severe clinical course of the EAE model, which was accompanied by increased glial activation, exacerbated spinal cord damage, and axonal degeneration as well as increased levels of proinflammatory cytokines (Johnson et al., 2010

In some embodiments, the otic formulation or composition comprises about 18% by weight of the poloxamer