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The spatial resolution of the ISRM varies depending on population density between 1 km by 1 km in dense urban areas to 48 km by 48 km in rural areas 12

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One historian of tobacco added that Hall found in a pipe a remedy for the melancholy, approaching to positive insanity, with which he was afflicted in his younger years. 34 Joseph Fume [William Chatto], A Paper: of Tobacco

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