- [Retatrutide Phase 2 Trial Supplementary Appendix: Drug Preparation]( *New England Journal of Medicine*, 2023
The potential for NLY01 to protect the myelin sheath in the context of MS is unknown
BENZODIAZEPINE WITHDRAWAL SYMPTOMS PSYCHOLOGICAL SYMPTOMS Excitability (jumpiness, restlessness) Insomnia, nightmares, other sleep disturbances Increased anxiety, panic attacks Agoraphobia, social phobia Perceptual distortions Depersonalisation, derealisation Hallucinations, misperceptions Depression Obsessions Paranoid thoughts Rage, aggression, irritability Poor memory and concentration Intrusive memories Craving (rare) PHYSICAL SYMPTOMS Headache Pain/stiffness (limbs, back, neck, teeth, jaw) Tingling, numbness, altered sensation (limbs, face, trunk) Weakness (jelly-legs) Fatigue, influenza-like symptoms Muscle twitches, jerks, tics, electric shocks Tremor Dizziness, light-headedness, poor balance Blurred/double vision, sore or dry eyes Tinnitus Hypersensitivity (light, sound, touch, taste, smell) Gastrointestinal symptoms (nausea, vomiting, diarrhoea, constipation, pain, distension, difficulty swallowing) Appetite/weight change Dry mouth, metallic taste, unusual smell Flushing/sweating/palpitations Overbreathing Urinary difficulties/menstrual difficulties Skin rashes, itching Fits (rare) These symptoms have all been described by patients withdrawing from benzodiazepines
Angiotensin IV analogs and hepatocyte growth factor receptor signaling
