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The contraindications are due to health concerns

Braman RS, Hendrix SA

Reduced Glutathione Level Promotes Epithelial-Mesenchymal Transition in Lens Epithelial Cells via a Wnt/beta-Catenin-Mediated Pathway: Relevance for Cataract Therapy

While comprehensive cost-effectiveness analyses are limited, silymarin is often considered an economically viable option due to its availability and relatively low cost compared to some pharmaceutical treatments