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However, early clinical studies of other modalities such as topical methylene blue and hypericin, as well as systemic 5-ALA and verteporfin, have demonstrated that these PSs are potent and much better tolerated than topical 5-ALA

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Early impairment of NGF/TrkA signaling in AD can lead to reduced synaptic vesicle secretion and decreased presynaptic protein expression, resulting in presynaptic functional impairment of cholinergic primary neurons [88]

Complex it with a copper 2+ ion, encapsulate it for stability, and you can push the effective hydrodynamic radius well past the cutoff