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In: Handbook of Critical Care Nephrology

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In the present review, we made an attempt to summarize the major aspects of the function of the l-arginine-NO system, from cellular l-arginine uptake to l-arginine catabolism by NOS to NO, arginase to l-ornithine and downstream metabolites, arginine methylation, and l-arginine-NO related oxidative stress

These data, together with mechanistic work showing that insulin stimulates VEGF and IGF production while glucose primes macrophages for inflammatory cytokine release 394 , suggest that the combination of high glucose and high insulin is more deleterious than hyperglycemia alone