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The honest answer is that it varies based on several factors: Acute injuries typically respond faster than chronic conditions that have developed over years

Nakamura Y, Walker BR, Ikuta T (2016) Elevated plasma cortisol following fasting

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If it does not dissolve after 5 minutes of gentle swirling, possible causes include: degraded peptide (check storage history and expiration status ), contaminated water (use a fresh vial of bacteriostatic water), or water temperature (cold water from the refrigerator dissolves peptides more slowly than room temperature water)