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1 (2016): 103-113, accessed April 13, 2020, doi: 10.1165/rcmb.2015-0045OC

The two peptides work through complementary mechanisms: tesamorelin stimulates anterior pituitary somatotrophs to release endogenous growth hormone (GH) through GHRH receptor activation, while ipamorelin amplifies GH pulse amplitude without stimulating prolactin or cortisol release, a selectivity advantage over earlier secretagogues like GHRP-6