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Oxidative modifications of synovial proteins contribute to the formation of neo-antigens, triggering autoimmune responses [145]

Under in vitro conditions, graphene oxide quantum dots alleviated 1-methyl-4-phenyl-pyridinium ion (MPP + )-induced oxidative stress and apoptosis

Inflammatory mediators such as cytokines, growth factors and chemokines and immune cells can cause direct damage to peripheral nerves, leading to neuropathic pain (McWilliams and Walsh, 2017)