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On the other hand, treatment with MchDMSA showed significant recovery of blood, liver and kidney ALAD, liver and kidney ALAS, GSH and GSSG, kidney TBARS and brain SOD levels

Experimental studies demonstrate that L-lactate administration (100 mM, 2 L) into the cerebral ventricles 30 min post-MCAO reduces infarct volume, neuronal apoptosis, and functional deficits [181]

Interestingly, introduction of carboxylic acid groups to RT slows down its reaction kinetics towards GSH comparing to RT-NH 2 and TQG-CN (Table 2), presumably due to the charge repulsion between the carboxylic acid groups and the anionic GSH

Additionally, BV-induced apoptosis in rheumatoid synovial fibroblasts has been shown to play a critical role in mitigating synovial hyperplasia, a hallmark of RA