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131 7.0g) (Table 1)

Goje et al., 2023

With regard to distribution , for drugs such as diazepam 1 and penfluridol 5 that are substantially distributed into adipose tissue, greater adiposity is associated with greater storage of the drug in lipid reservoirs, and hence greater availability of the drug for return to blood as blood levels fall due to metabolism

In accordance with these observations, addition of thiamine and ThMP modulate synaptic transmission, electric and contractile activity of the smooth muscle strips from gastrointestinal tract (247)