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In trying to protect your mind from the neuro-chemical influence of the toxic natural pesticide nicotine, in some brain regions it actually desensitized important neuro-chemical circuits by reducing neurotransmitter receptor sites (down-regulation), in other regions by increasing the number of receptors (up-regulation), and still others by diminishing the number of transporters

And if you smoke yourself to death, Tell Saint Peter at the golden gate, That you hates to make him wait, But you gotta have another cigarette

Irritation of the mucous membranes leads to throat discomfort and inflammation, creating a cycle of soreness and coughing

You seem annoyed about something