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Flavonoids are known to possess protective effects in biological systems due to their capacity to transfer free radical electrons, chelate metal catalysts, activate antioxidant enzymes, reduce alpha-tocopherol radicals, and inhibit oxidases [43]

Apathy related pathology Apathy in AD is most commonly associated with pathological changes of the anterior cingulate cortex (ACC), which include cortical thinning, atrophy, low fractional anisotropy (FA) scores, amyloid accumulation, hypometabolism, and neurofibrillary tangles (Tighe et al., 2012

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