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To advance clinical application, future research should develop multimodal biomarker panels by integrating technologies such as mass spectrometry imaging, spatial transcriptomics, and single-cell lipidomics, combined with artificial intelligence to define a distinct ferroptosis signature in neurodegeneration

This pulsatile GH output then promotes hepatic and peripheral IGF1 production, supporting anabolic processes such as protein synthesis, lipolysis, and tissue repair

NICE guidance on obesity management (CG189) emphasises evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, andwhere appropriatepharmacotherapy with licensed medications such as orlistat or semaglutide (NICE TA875)

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