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2010;298:E8998

This creates a more stable concentration in the bloodstream, often allowing for once-daily dosing rather than multiple doses throughout the day

2009:60 Suppl 7:191-196

Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics The concomitant use of opioids with other opioid analgesics, such as butorphanol, nalbuphine, pentazocine, may reduce the analgesic effect of Hydrocodone Bitartrate and Acetaminophen Tablets and/or precipitate withdrawal symptoms