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Declining energy production, impaired DNA repair, oxidative stress, and chronic low-grade inflammation contribute to: Dull tone Reduced elasticity Textural changes Slower healing Increased sensitivity Accelerated visible aging NAD+ (nicotinamide adenine dinucleotide) is essential for cellular metabolism and repair

Organic acid analytes are extracted from urine and derivatized before being analyzed by GC/MS

The transition metals copper, zinc and iron are all enriched in Abeta plaques

Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation