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Here we report the protective effect of clofazimine against infection with SARS-CoV-2 or MERS-CoV in primary human cells and in a hamster model

The potential molecular mechanisms underlying these effects included disturbances in redox homeostasis (as evidence by the enhanced production of ROS and reactive nitrogen species), failure of enzymatic and nonenzymatic cytoprotective mechanisms involving the glutathione system as well as nuclear factor kappa B (NF-B) and fibroblast growth factor 2-mediated pathways, and impaired mitochondrial function

Water temperature matters more than you might think

Statistical analysis Data are presented as means standard error of the mean (SEM)