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Reduction of Inflammation: The anti-inflammatory properties of both active ingredients can reduce skin inflammation, leading to calmer, less irritated skin
Overall, further mechanistic studies are needed in the future to validate the therapeutic potential of TNF- and the inhibitors and inducers of ferroptosis in EBV-related diseases
After 24 h, cell cycle phases were examined by flow cytometry to select the optimal dose as the working concentration
Disruption in iron homeostasis, including increased transferrin receptor expression and ferritin degradation via NCOA4-mediated ferritinophagy, contributes to ferroptotic susceptibility ( Lipid Peroxidation: Polyunsaturated fatty acids (PUFAs), especially arachidonic and adrenic acids, are substrates for lipoxygenases (LOX), which drive peroxidation in membrane phospholipids, generating cytotoxic lipid peroxides such as 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA) ( Glutathione Depletion and GPX4 Inactivation: System Xc imports cystine for GSH synthesis
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