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As such, niclosamide can inhibit virus replication as demonstrated in Vero 6 cells at only 1M (10) and has also been shown to have similar anti-replicative efficacy in cultured Calu-3 lung cells, at 2M (34)

PAXLOVID is contraindicated with drugs that are primarily metabolized by CYP3A and for which elevated concentrations are associated with serious and/or life-threatening reactions and drugs that are strong CYP3A inducers where significantly reduced nirmatrelvir or ritonavir plasma concentrations may be associated with the potential for loss of virologic response and possible resistance

European Neurology (1987) 7

Sterility testing is not part of our standard batch documentation