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716,717 Interestingly, MRI confirmed higher iron levels in stroke patients, and iron levels in the brain were associated with the severity of cerebral infarction, while iron-dependent lipid peroxidation, or ferroptosis, occurred in neurons in the infarct area during ischemic stroke

APEX1 inhibitors induce cell death, such as apoptosis and pyroptosis [124], while iron significantly inhibits APEX1 activity, exacerbating the damage to cells caused by oxidative stress [125]