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Cleavage by extracellular proteases converts the precursor into a two-chain functional heterodimer

This results in chronic, low grade inflammation termed metaflammation (72) which is central to insulin resistance and disruption of insulin receptor signaling (73), and requires the participation of both immune and non-immune cells

doi:10.3390/molecules16119234 Hamadi N, Mansour A, Hassan MH, Khalifi-Touhami F, Badary O (2012) Ameliorative effects of resveratrol on liver injury in streptozotocin-induced diabetic rats

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