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When used in combination, NAC and cisplatin may enhance the cytotoxic effects on cancer cells while simultaneously protecting normal cells by mitigating oxidative damage [516, 517], and the combination can also reduce side effects such as ototoxicity caused by cisplatin administration [518]

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Moreover, none of the included studies conducted systematic analyses of small moleculeprotein interactions, and the pharmacokinetic relevance of the doses used in vitro versus in vivo studies remains largely unaddressed

Assessing and mining grain amaranth diversity for sustainable cropping systems