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Hepatic IRE1alpha regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARalpha axis signalling

doi: 10.1016/j.ogc.2016.04.001

This interaction inhibits Keap1-mediated ubiquitination and degradation of NRF2, resulting in the upregulation of antioxidant genes and contributing to chemotherapy resistance in NSCLC [100]