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Biologic therapeutics as Ovary-Sparing alternatives in oncologic care A growing portfolio of biologic agentsrecombinant proteins, monoclonal antibodies, and antibodydrug conjugates (ADCs)is reshaping systemic therapy for both ovarian and extra-ovarian malignancies, offering tumour-selective efficacy with substantially less collateral gonadotoxicity than classical cytotoxics [144]

Before NMR analysis, the sample was reconstituted in 50 l of precooled 4 C methanol, centrifuged at 18,500 g for 10 minutes at 4 C and the resulting supernatant was transferred into a precooled 2 ml Eppendorf and then stored at -80 C [25]

doi: 10.1016/j.jare.2021.10.001 36 ZhengYLiuLShuklaGC

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