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Clinical and preclinical trials demand microbiome-targeted strategies which should necessarily be based on rigorous, widespread, large-scale, and long-term experiments to further validate the safety and efficacy

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A previous study on the association between KEGG pathways and AD revealed that the pathways most closely related to AD pathology-associated genes or targets of approved AD drugs were not necessarily the most extensively studied, highlighting a disconnect between drug development and mechanism research [3]

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