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Specifically, in Mexican mestizo subjects, there is an association between several genetics variants: codifying for cholinergic receptor nicotinic 4 and 2 subunits (CHRNA4, CHRNB2), DRD2, ankyrin repeat and kinase domain containing 1 protein (ANKK1), dopamine transporter (SLC6A3), and the hepatic enzyme responsible for nicotine metabolism (CYP2A6) and cigarette consumption, the age of initiation, and the duration of smoking 21

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