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In studies comparing HBV-related liver disease patients with healthy controls, genetic polymorphisms of CR1 were associated with the risk of male HBV-related HCC [61]

Several research groups have attempted to delineate the underlying mechanisms of irAEs, as curated by the authors of the Cancer Immunology Research paper below

Alongside observable behavioral declines, such as a loss of self-care abilities, they continue to be the primary outcome measures recognized by regulatory agencies for assessing therapeutic efficacy